Inhibitors of p38

Details Inhibitors of p38 Inhibitors of p38

C - Chemistry, Metallurgy

07

C

C07C 275/28 (2006.01) A61K 31/17 (2006.01) A61K 31/415 (2006.01) C07C 275/30 (2006.01) C07C 275/34 (2006.01) C07C 275/38 (2006.01) C07C 275/40 (2006.01) C07C 275/42 (2006.01) C07C 311/47 (2006.01) C07D 209/08 (2006.01) C07D 213/06 (2006.01) C07D 213/75 (2006.01) C07D 215/40 (2006.01) C07D 231/56 (2006.01) C07D 277/64 (2006.01) C07D 277/82 (2006.01) C07D 295/135 (2006.01) C07D 307/91 (2006.01) C07D 317/66 (2006.01) C07D 319/18 (2006.01)

Patent

CA 2294463

The present invention relates to inhibitors of p38, a mammalian protein kinase involved in cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.

Cette invention se rapporte à des inhibiteurs de p38, une protéine kinase de mammifères impliquée dans la prolifération cellulaire, la mort cellulaire et la réponse à des stimuli extracellulaires. Cette invention se rapporte également à des procédés de production de ces inhibiteurs, à des compositions pharmaceutiques contenant ces inhibiteurs et à des procédés d'utilisation de ces compositions dans le traitement et la prévention de divers troubles.

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