Inhibitors of phosphodiesterases in infertility

Details Inhibitors of phosphodiesterases in infertility Inhibitors of phosphodiesterases in infertility

A - Human Necessities

61

K

A61K 31/519 (2006.01) A61K 31/277 (2006.01) A61K 31/44 (2006.01) A61K 31/4745 (2006.01) A61K 31/4985 (2006.01) A61K 38/24 (2006.01) A61K 45/06 (2006.01) A61P 15/08 (2006.01)

Patent

CA 2517487

The present invention is directed to methods of increasing oocyte production in a mammal. More specifically, the specification describes methods and compositions for inducing follicular maturation using a PDE inhibitor. The inhibitor may be used alone at high doses. Alternatively, the follicular maturation is achieved by combining a low dose of FSH with the PDE inhibitor treatment.

La présente invention a trait à des procédés d'accroissement de production d'ovocytes chez un mammifère. De manière plus spécifique, l'invention a trait à des procédés et des compositions pour induire la maturation folliculaire au moyen d'un inhibiteur de phosphodiestérases. L'inhibiteur peut être utilisé seul à des doses très élevées. En variante, la maturation folliculaire est réalisée par la combinaison d'une faible dose d'hormone folliculostimulante avec le traitement par inhibiteurs de phosphodiestérases.

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