C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/38 (2006.01) A61K 31/66 (2006.01) C12N 9/20 (2006.01)
Patent
CA 2173456
The present invention is directed to novel .alpha.-hydroxy-phosphonate compounds which inhibit mammalian phosphoinositide-specific phospholipase-C. The compounds are potent inflammatory and analgesic agents and may be useful for the treatment of cancer.
L'invention a pour objet de nouveaux composés alpha-hydroxy-phosphonate qui inhibent la phospholipase-C spécifique du phosphoinositide du mammifère. Ces composés constituent de puissants agents anti-inflammatoires et analgésiques, et peuvent être utiles dans le traitement du cancer.
Gibbs Jackson B.
Koblan Kenneth S.
Macleod Angus M.
Merchant Kevin J.
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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