Inhibitors of picornavirus 3c proteases and methods for...

Details Inhibitors of picornavirus 3c proteases and methods for... Inhibitors of picornavirus 3c proteases and methods for...

C - Chemistry, Metallurgy

07

K

C07K 5/027 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) C07C 237/22 (2006.01) C07C 271/22 (2006.01) C07C 311/06 (2006.01) C07C 311/13 (2006.01) C07C 311/19 (2006.01) C07D 209/42 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) C07K 5/078 (2006.01)

Patent

CA 2254343

Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of picornaviral 3C proteases. These compounds, as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses. Several novel methods and intermediates can be used to prepare the novel picornaviral 3C protease inhibitors of the present invention.

Des inhibiteurs de 3C protéase picornavirale, qu'on peut obtenir par synthèse chimique, inhibent ou bloquent l'activité biologique des 3C protéases picornavirales. Ces composés, de même que les compositions pharmaceutiques les contenant, sont utiles au traitement des patients ou des hôtes infectés par un ou plusieurs picornavirus. Plusieurs méthodes et intermédiaires nouveaux peuvent être utilisés pour préparer les nouveaux inhibiteurs de 3C protéases picornavirales décrits.

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