Inhibitors of polyq-aggregation

C - Chemistry – Metallurgy – 07 – D

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C07D 277/82 (2006.01) A61K 31/4245 (2006.01) A61K 31/425 (2006.01) A61K 31/428 (2006.01) A61K 31/47 (2006.01) A61K 31/4745 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61P 3/00 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 7/00 (2006.01) A61P 7/02 (2006.01) A61P 7/06 (2006.01) A61P 7/08 (2006.01) A61P 9/00 (2006.01) A61P 13/02 (2006.01) A61P 13/12 (2006.01) A61P 19/00 (2006.01) A61P 19/04 (2006.01) A61P 21/00 (2006.01) A61P 25/00 (2006.01) A61P 25/14 (2006.01) A61P 25/16 (2006.01) A61P 25

Patent

CA 2456868

Compounds of formula I, wherein R1, R2, R3, R4 and R5 have the meanings as given in claim 1, and their pharmaceutically tolerable derivatives, solvates and stereoisomers and their use for the preparation of a pharmaceutical for inhibiting the formation of polyQ-aggregation.

L'invention concerne des composés représentés par la formule (I), dans laquelle R?1¿, R?2¿, R?3¿, R?4¿ et R?5¿ sont tels que décrits dans la revendication (1), leurs dérivés, solvates et stéréo-isomères pharmaceutiquement acceptables, ainsi que leur utilisation dans la préparation d'un produit pharmaceutique pour inhiber la formation de polyQ-agrégation.

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