A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7012 (2006.01) A61K 31/7008 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2692419
The invention relates to inhibitors of polysialic (PSA) de-N-acetylase, methods of their production and use. The methods involve use of a PSA de-N-acetylase inhibitor for modifying the growth of cells, such as inhibiting the growth of cancer cells. The compositions include an inhibitor of a PSA de-N-acetylase, such as N-substituted derivatives of the amino sugars hexosamine and neuraminic acid, as well as conjugates and aggregates. Also provided are pharmaceutical compositions that include a PSA de-N-acetylase inhibitor of the invention. Kits containing one or more inhibitor compositions of the invention, as well as methods of preparing the compositions also are provided.
L'invention se rapporte à des inhibiteurs de l'acide polysialique (PSA) de-N-acétylase, à des procédés pour leur production et à leur utilisation. Les procédés comprennent l'utilisation d'un inhibiteur de PSA de-N-acétylase pour modifier la croissance des cellules comme l'inhibition de la croissance de cellules cancéreuses. Les compositions comprennent un inhibiteur d'une PSA de-N-acétylase, comme des dérivés N-substitués des sucres aminés hexosamine et acide neuraminique ainsi que des conjugués et des agrégats. Des compositions pharmaceutiques incluant un inhibiteur de PSA de-N-acétylase de l'invention sont aussi incluses. Des kits contenant une ou plusieurs compositions de l'invention incluant des inhibiteurs ainsi que des procédés de préparation des compositions sont également fournis.
Hagen Brent T.
Moe Gregory R.
Children's Hospital & Research Center At Oakland
Fetherstonhaugh & Co.
LandOfFree
Inhibitors of polysialic acid de-n-acetylase and methods for... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Inhibitors of polysialic acid de-n-acetylase and methods for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of polysialic acid de-n-acetylase and methods for... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1614698