Inhibitors of prenyl-protein transferase

Details Inhibitors of prenyl-protein transferase Inhibitors of prenyl-protein transferase

C - Chemistry, Metallurgy

07

D

C07D 401/02 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2305783

The present invention is directed to compounds which inhibit prenyl-protein transferase (FTase) and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.

L'invention porte sur des composés inhibiteurs de la prényl-protéine transférase (FTase), sur la prénylation de la protéine oncogène Ras, sur des compositions chimiothérapeutiques contenant les composés de l'invention, et sur des procédés d'inhibition de la prényl-protéine transférase et de prénylation de la protéine oncogène Ras.

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