Inhibitors of prenyl-protein transferase

Details Inhibitors of prenyl-protein transferase Inhibitors of prenyl-protein transferase

C - Chemistry, Metallurgy

07

D

C07D 498/08 (2006.01) A61K 31/337 (2006.01) A61K 31/415 (2006.01) A61K 31/4178 (2006.01) A61K 45/06 (2006.01) A61K 47/48 (2006.01) C07D 498/18 (2006.01)

Patent

CA 2384151

The present invention is directed to macrocyclic compounds which inhibit prenyl-protein transferase (FTase) and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl- protein transferase and the prenylation of the oncogene protein Ras.

L'invention concerne des composés macrocycliques inhibiteurs de la prényl-protéine transférase (FTase) et la prénylation de la protéine oncogène Ras. L'invention concerne en outre des compositions chimiothérapeutiques renfermant lesdits composés, ainsi que des procédés relatifs à l'inhibition de la prényl-protéine transférase et de la prénylation de la protéine oncogène Ras.

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