A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/415 (2006.01) A61K 31/00 (2006.01) C07D 267/22 (2006.01) C07D 281/18 (2006.01) C07D 291/00 (2006.01) C07D 337/16 (2006.01) C07D 487/00 (2006.01) C07D 498/00 (2006.01) C07D 513/00 (2006.01)
Patent
CA 2336054
The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
La présente invention concerne des composés macrocycliques peptidomimétiques inhibant une prényl-protéine transférase et la prénylation de la protéine oncogène Ras. L'invention concerne également des compositions chimiothérapeutiques contenant les composés de la présente invention et des méthodes d'inhibition d'une prényl-protéine transférase et de la prénylation de la protéine oncogène Ras.
Anthony Neville J.
Bell Ian M.
Beshore Douglas C.
Ciccarone Terrence M.
Desolms S. Jane
Gowling Lafleur Henderson Llp
Merck And Co. Inc.
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