Inhibitors of prenyl-protein transferase

Details Inhibitors of prenyl-protein transferase Inhibitors of prenyl-protein transferase

C - Chemistry, Metallurgy

07

D

C07D 498/08 (2006.01) A61K 31/415 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2336448

The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.

L'invention concerne des composés peptidomimétiques macrocycliques inhibant la prényl-protéine transférase et la prénylation de la protéine oncogène Ras. L'invention concerne en outre des compositions chimiothérapeutiques renfermant les composés considérés, ainsi que des procédés relatifs à l'inhibition de la prényl-protéine transférase et de la prénylation de la protéine oncogène Ras.

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