C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/18 (2006.01) A61K 31/495 (2006.01)
Patent
CA 2336475
The present invention is directed to peptidomimetic piperazine-containing macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
La présente invention concerne des composés macrocycliques contenant une pipérazine peptidomimétiques qui inhibe une prényl-protéine transférase et la prénylation de la protéine oncogène Ras. L'invention concerne en outre des compositions chimiothérapeutiques contenant les composés de la présente invention et des méthodes d'inhibition d'une prényl-protéine transférase et de la prénylation de la protéine oncogène Ras.
Bergman Jeffrey M.
Dinsmore Christopher J.
Graham Samuel L.
Nguyen Diem N.
Stokker Gerald E.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
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