Inhibitors of production and/or secretion of amyloid-.beta....

Details Inhibitors of production and/or secretion of amyloid-.beta.... Inhibitors of production and/or secretion of amyloid-.beta....

C - Chemistry, Metallurgy

07

C

C07C 235/10 (2006.01) A61K 31/165 (2006.01) A61K 31/166 (2006.01) A61K 31/18 (2006.01) A61K 31/216 (2006.01) A61K 31/40 (2006.01) A61K 31/4453 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) C07C 217/60 (2006.01) C07C 233/87 (2006.01) C07C 235/34 (2006.01) C07C 235/50 (2006.01) C07C 237/22 (2006.01) C07C 237/42 (2006.01) C07C 237/44 (2006.01) C07C 311/21 (2006.01) C07D 213/82 (2006.01) C07D 295/088 (2006.01) C07D 295/12 (2006.01) C07D 295/13 (2006.01)

Patent

CA 2351692

Compounds represented by general formula (I), salts thereof or prodrugs of the same which exhibit an excellent effect of inhibiting .beta.-amyloid protein production/secretion, wherein Ar represents an aromatic group; X and Y represent each a divalent group selected from among -O-, -S-, -CO-, -SO-, -SO2- , -NR8-, -CONR8-, -SO2NR8- and -COO- (wherein R8 represents H, hydrocarbyl or acyl), or divalent aliphatic C1-6 hydrocarbyl optionally containing one or two of these divalent groups; R1 and R2 represent each H or C1-6 alkyl, or R1 and R2 may form together with the nitrogen atom adjacent thereto a nitrogen- containing heterocycle; and the ring A represents a monocyclic aromatic ring.

L'invention concerne des composés correspondant à la formule générale (I) et leurs sels ou promédicaments qui ont un excellent effet inhibiteur sur la production/la sécrétion de protéine .beta.-amyloïde dans laquelle Ar représente un groupe aromatique; X et Y représentent chacun un groupe divalent sélectionné parmi -0-, -S-, -CO-, -SO-, -SO¿2?-, -NR?8¿-, -CONR?8¿-, -SO¿2?NR?8¿- et -COO- (dans lesquels R?8¿ représente H, hydrocarbyle ou acyle) ou un hydrocarbyle C¿1-6? aliphatique divalent contenant en option un ou deux de ces groupes divalents; R?1¿ et R?2¿ représentent chacun H ou un alkyle C¿1-6?, ou R?1¿ et R?2¿ peuvent former conjointement avec l'atome d'azote adjacent un hétérocycle contenant azote; et dans lesquels le noyau A représente un noyau aromatique monocyclique.

Affiliated with

Also associated with

Rating

Inhibitors of production and/or secretion of amyloid-.beta.... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibitors of production and/or secretion of amyloid-.beta...., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of production and/or secretion of amyloid-.beta.... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1912974