A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/713 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2652768
The present invention relates to inhibitors of progastrin induced repression of ICAT for treating and/or preventing colorectal cancer, adenomatous polyposis or metastasis displaying progastrin-secreting cells and cells in which the beta-catenin/Tcf-4-mediated transcriptional pathway is constitutively active.
La présente invention concerne des inhibiteurs de la répression induite par la prostaglandine de ICAT dans le traitement et/ou la prévention du cancer colorectal, de la polypose adénomateuse ou de métastases présentant des cellules sécrétant de la prostaglandine et des cellules dans lesquelles la voie transcriptionnelle à médiation par la bétacaténine/TEF-4 est constitutivement active.
Bourgaux Jean-Francois
Delaunay Nathalie
Hollande Frederic
Jay Philippe
Joubert Dominique
Centre National de La Recherche Scientifique-Cnrs
Inserm (institut National de La Sante Et de La Recherche Medical
Robic
Universite de Montpellier I.
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