Inhibitors of proteasomal activity for stimulating bone and...

A - Human Necessities – 61 – K

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A61K 38/06 (2006.01) A61K 31/00 (2006.01) A61K 31/40 (2006.01) A61K 31/4015 (2006.01) A61K 38/05 (2006.01) A61K 45/06 (2006.01) A61P 17/14 (2006.01) A61P 19/08 (2006.01)

Patent

CA 2337988

Compounds that inhibit the activity of NF-B or inhibit the activity of the proteasome or both promote bone formation and hair growth and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, and post-dental implantation; they also stimulate the production of hair follicles and are thus useful in stimulating hair growth, including hair density, in subject where this is desirable.

L'invention concerne des composés qui inhibent l'activité de NF-?B ou l'activité protéasomique ou qui stimulent à la fois la formation osseuse et la croissance capillaire. Par conséquent, ces composés sont utiles dans le traitement de l'ostéoporose, des fractures ou déficiences osseuses, de l'hyperparathyroïdie primaire ou secondaire, des parodontopathies, des troubles osseux métastatiques, des maladies ostéolytiques, des états suivant la chirurgie plastique et la chirurgie d'implantation de prothèses d'articulation ainsi que des états suivant les implantations dentaires. Ces composés sont également utiles pour stimuler la production des follicules capillaires et donc la croissance capillaire, y compris la densité capillaire, chez les sujets pour lesquels un tel traitement est souhaitable.

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