A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/06 (2006.01) A61K 8/64 (2006.01) A61K 31/00 (2006.01) A61K 31/165 (2006.01) A61K 31/351 (2006.01) A61K 31/365 (2006.01) A61K 31/4015 (2006.01) A61K 31/522 (2006.01) A61K 38/07 (2006.01) A61K 38/13 (2006.01) A61P 19/00 (2006.01) A61P 43/00 (2006.01) A61Q 7/00 (2006.01)
Patent
CA 2385958
Compounds that inhibit the activity of NF-.kappa.B or inhibit the activity of the proteasome or both promote bone formation and hair growth and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, and post-dental implantation; they also stimulate the production of hair follicles and are thus useful in stimulating hair growth, including hair density, in subject where this is desirable.
La présente invention concerne des composés inhibiteurs de l'activité du NF-.kappa.B ou inhibiteurs de l'activité de protéasome ou promoteurs à la fois de la croissance osseuse et de la pousse des cheveux et sont, par conséquent, utiles dans le traitement de l'ostéoporose, la fracture de l'os ou la déficience osseuse, l'hyperparathyroïdisme primaire ou secondaire, la maladie ou l'anomalie paradontale, la maladie osseuse métastasique, la maladie osseuse ostéolytique, les soins de post-chirurgie plastique, de post-chirurgie d'articulation prothésée, de post-implantation dentaire; lesdits composés favorisent également la pousse des cheveux, y compris en volume, chez un sujet où cela est désirable.
Garrett Ross I.
Mundy Gregory R.
Rossini Giovanni
Fetherstonhaugh & Co.
Osteoscreen Inc.
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