Inhibitors of protein aggregation

Details Inhibitors of protein aggregation Inhibitors of protein aggregation

A - Human Necessities

61

K

A61K 31/5415 (2006.01) A61K 49/00 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2645946

The invention relates generally to the use of diaminophenothiazine compounds to inhibit or reverse the aggregation of synuclein, and for their use in the manufacture of medicaments for this purpose (e.g. for the treatment of Parkinson's Disease). Also provided are related methods of detecting or labelling of aggregated synuclein.

L'invention concerne, de manière générale, l'utilisation de composés de diaminophénothiazine pour inhiber ou inverser l'agrégation de la synucléine, ainsi que l'utilisation de ces composés dans la fabrication de médicaments à cet effet (par exemple, dans le traitement de la maladie de Parkinson). Par ailleurs, l'invention concerne des procédés de détection ou de marquage de synucléine formant agrégat.

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