Inhibitors of protein kinases

Details Inhibitors of protein kinases Inhibitors of protein kinases

C - Chemistry, Metallurgy

07

D

C07D 403/02 (2006.01) A61K 31/381 (2006.01) A61K 31/4155 (2006.01) A61K 31/445 (2006.01) A61P 19/02 (2006.01) A61P 35/00 (2006.01) C07D 403/14 (2006.01) C07D 405/02 (2006.01) C07D 405/14 (2006.01) C07D 407/02 (2006.01) C07D 407/14 (2006.01) C07D 411/02 (2006.01) C07D 411/14 (2006.01) C07D 413/02 (2006.01) C07D 413/04 (2006.01) C07D 417/02 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2589274

The present invention is directed to a compound having the formula (I) wherein R1, R2, R3, R4, G, and Q are defined herein. The compounds of the present invention are useful as inhibitors of protein kinases. The present invention is also directed to compositions comprising a compound according to the above formula. The present invention is also directed to compounds that stabilize the open conformation of a protein kinase, a crystallized protein kinase in the open conformation, and uses thereof. The compounds and compositions described herein are useful for treating and preventing an inflammatory condition or disease.

L'invention concerne un composé de formule (I) dans laquelle R1, R2, R3, R4, G et Q sont tels que définis dans la description. Les composés selon l'invention sont utiles comme inhibiteurs de protéines kinases. L'invention concerne également des compositions renfermant un composé selon la formule susmentionnée. L'invention concerne, en outre, des composés stabilisant la conformation ouverte d'une protéine kinase, une protéine kinase cristallisée en conformation ouverte et l'utilisation de ceux-ci. Les composés et compositions selon l'invention sont utiles dans le traitement et la prévention d'un état ou d'une maladie inflammatoire.

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