C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 31/519 (2006.01) A61P 9/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 239/48 (2006.01) C07D 401/14 (2006.01)
Patent
CA 2723185
The present invention is directed to compounds of formula (I)-(II) and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.
La présente invention concerne des composés de formules (I)-(II) et leurs sels, esters et promédicaments de qualité pharmaceutique, qui sont des inhibiteurs de la kinase Syk et/ou Jak. La présente invention concerne également des intermédiaires utilisés dans la fabrication de tels composés, la préparation dun tel composé, des compositions pharmaceutiques contenant un tel composé, des méthodes dinhibition de lactivité de la kinase Syk et/ou Jak, des méthodes dinhibition de lagrégation plaquettaire, et des méthodes permettant de prévenir ou de traiter un certain nombre daffections médiées au moins en partie par lactivité de la kinase Syk et/ou Jak, telles que la thrombose non souhaitée et le lymphome non hodgkinien.
Bauer Shawn M.
Jia Zhaozhong J.
Mehrotra Mukund
Pandey Anjali
Song Yonghong
Fetherstonhaugh & Co.
Portola Pharmaceuticals Inc.
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