Inhibitors of protein tyrosine kinase activity

Details Inhibitors of protein tyrosine kinase activity Inhibitors of protein tyrosine kinase activity

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/4365 (2006.01)

Patent

CA 2717816

This invention relates to compounds that inhibit protein tyrosine kinase activity. In particular the invention relates to compounds that inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signaling, for example, the inhibition of VEGF receptor signaling. The invention also provides compounds, compositions and methods for treating cell proliferative diseases and conditions and opthalmological diseases, disorders and conditions.

Cette invention porte sur des composés qui inhibent l'activité de protéine tyrosine kinase. En particulier, l'invention porte sur des composés qui inhibent l'activité de protéine tyrosine kinase de récepteurs de facteurs de croissance, ce qui entraîne l'inhibition de la signalisation des récepteurs, par exemple l'inhibition de la signalisation des récepteurs du VEGF. L'invention porte également sur des composés, des compositions et des procédés pour traiter des maladies et affections prolifératives des cellules et des maladies, troubles et affections ophtalmologiques.

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