Inhibitors of purine nucleoside phosphorylase

Details Inhibitors of purine nucleoside phosphorylase Inhibitors of purine nucleoside phosphorylase

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) A61K 31/675 (2006.01) C07C 255/31 (2006.01) C07C 255/32 (2006.01) C07C 255/35 (2006.01) C07C 255/40 (2006.01) C07C 255/42 (2006.01) C07D 207/34 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 2072123

Disclosed is a compound containing a 2-amino-7-(R)-3H,5H-pyrrolo[3,2- a]pyrimidin-4-one wherein K is cyclohexeny cyclohexyl, or -CH2-R1, and wherein R1 is an optionally substituted heteroalicyclic, pyridinyl or alicyclic group. Also dis- closed is a compound of formula (I), wherein R1 is H, NH2, or OCH3, R2 is an optionally substituted cyclic group of 5- carbon atoms optionally containing one or more heteroatoms, R3 and R4 are independently H or C1-4 alkyl, m is 0-4, n is 0-6, p is 0-1, X is CN, CSNH2, PO(OH)2, COOH, SO2NH2, NH2, OH CNHNH2, tetrazole, or triazole, COR5 where R5, C1-4 alkyl, CF3, NH2, or OC1-4 alkyl, and Y is O or NH.

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