Inhibitors of pyruvate kinase and methods of treating disease

Details Inhibitors of pyruvate kinase and methods of treating disease Inhibitors of pyruvate kinase and methods of treating disease

A - Human Necessities

61

K

A61K 31/426 (2006.01) A61K 31/381 (2006.01) A61K 31/402 (2006.01) A61K 31/4184 (2006.01) A61K 31/4196 (2006.01) A61K 31/506 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2659956

The invention provides pharmaceutical compositions, kits, and methods of treating cancer, diabetes, obesity, autoimmune disease, and benign prostatic hyperplasia using compounds that selectively inhibit pyruvate kinase M2 and an assay measuring chemical modulation of pyruvate kinase activity.

L'invention concerne des compositions pharmaceutiques, des coffrets et des procédés pour traiter le cancer, le diabète, l'obésité, une maladie auto-immune et une hyperplasie prostatique bénigne au moyen de composés qui inhibent sélectivement la pyruvate kinase M2 ; l'invention concerne également un dosage permettant de mesurant la modulation chimique de l'activité pyruvate kinase.

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