C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/00 (2006.01) A61K 38/00 (2006.01) A61K 38/04 (2006.01) A61K 38/06 (2006.01) A61K 38/10 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) C07K 7/04 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/705 (2006.01) C12N 9/12 (2006.01)
Patent
CA 2447431
The present invention provides a RANK (receptor activator of NF-.kappa.B) inhibitor consisted of a TRAF-6 (TNF receptor-associated factor-6) binding domain attached to a leader sequence. The peptide inhibitor inhibits RANKL (RANK ligand)-mediated osteoclast differentiation, thus indicating that targeted disruption of interaction between RANK and TRAF6 may prove useful as a therapeutic for metabolic bone disorders, leukemia, arthritis, and metastatic cancer of the bone.
Cette invention se rapporte à un inhibiteur de RANK (récepteur activateur de NF-.kappa.B) composé d'un domaine de fixation de TRAF-6 (facteur 6 associé au récepteur TNF) attaché à une séquence leader. Cet inhibiteur peptidique inhibe la différenciation des ostéoclastes induite par RANKL (ligand RANK), indiquant ainsi qu'une interruption ciblée de l'interaction entre RANK et TRAF-6 peut se révéler utile comme thérapie contre les affections osseuses métaboliques, la leucémie, l'arthrite et le cancer métastatique des os.
Aggarwal Bharat
Darnay Bryant G.
Singh Sujay
Borden Ladner Gervais Llp
Research Development Foundation
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