Inhibitors of receptor tyrosine kinases and methods of use...

Details Inhibitors of receptor tyrosine kinases and methods of use... Inhibitors of receptor tyrosine kinases and methods of use...

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 14/71 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2687896

The present invention provides moieties that bind to an Ig-like domain, e.g., D4 or D5, of a human receptor tyrosine kinase, e.g., the human Kit RTK or the PDGFR RTK, or the D7 domain of a type V receptor tyrosine kinase wherein the moieties lock the ectodomain of the receptor tyrosine kinase in an inactive state thereby antagonizing the activity of the receptor tyrosine kinase.

Cette invention concerne des fractions qui se lient à un domaine de type Ig, D4 ou D5 par exemple, d'un récepteur tyrosine kinase humain, par exemple le Kit RTK humain ou PDGFR RTK, ou bien le domaine D7 d'un récepteur tyrosine kinase de type V, lesdites fractions bloquant l'ectodomaine du récepteur tyrosine kinase dans un état actif, avec pour effet d'antagoniser l'activité du récepteur tyrosine kinase.

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