Inhibitors of regiii proteins as asthma therapeutics

Details Inhibitors of regiii proteins as asthma therapeutics Inhibitors of regiii proteins as asthma therapeutics

C - Chemistry, Metallurgy

07

K

C07K 1/00 (2006.01) A61K 39/385 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2568345

Methods of screening for agents for treating asthma are provided. The methods involve screening for agents that decrease the production or activity of a RegIII protein that has been discovered herein to play a role in producing the symptoms and pathological complications involved in asthma. Methods of treating asthma, as well as screening for and treating with inhibitors of a RegIII protein are also provided.

L'invention porte sur des procédés de criblage d'agents de traitement de l'asthme. Lesdits procédés consistent à effectuer un criblage d'agents réduisant la production ou l'activité de la protéine RegIII dont l'invention a découvert qu'elle jouait un rôle dans la production des symptômes et complications pathologiques liées à l'asthme. L'invention porte également sur des procédés: de traitement de l'asthme, de criblage d'inhibiteurs de la protéine RegIII, et de traitement au moyen desdits inhibiteurs.

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