C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 243/18 (2006.01) A61K 31/15 (2006.01) C07C 239/08 (2006.01) C07C 243/16 (2006.01)
Patent
CA 2535403
Compositions and methods of using compositions for treatment of inflammatory diseases and immune disorders are provided. Allylhydrazine compounds, hydroxylamine (aminooxy) compounds, and other compounds are disclosed which are inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and/or vascular adhesion protein 1 (VAP-1). The compounds have therapeutic utility in suppressing inflammation and inflammatory responses, and in treatment of several disorders, including multiple sclerosis.
La présente invention se rapporte à des compositions et à des méthodes d'utilisation de compositions pour le traitement de maladies inflammatoires et de troubles immunitaires. L'invention se rapporte à des composés d'allylhydrazine, à des composés d'hydroxylamine (aminooxy), et à d'autres composés qui sont des inhibiteurs de l'amine oxydase sensible aux semicarbazides (SSAO) et/ou de la protéine 1 d'adhérence vasculaire (VAP-1). Ces composés présentent une utilité thérapeutique pour la suppression des inflammations et des réactions inflammatoires, et pour le traitement de plusieurs troubles, notamment de la sclérose en plaques.
Cockerill Keith
Linnik Matthew D.
Salter-Cid Luisa Maria
Victoria Edward J.
Wang Eric Yanjun
Borden Ladner Gervais Llp
La Jolla Pharmaceutical Company
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