Inhibitors of separase, method for identifying them and uses

Details Inhibitors of separase, method for identifying them and uses Inhibitors of separase, method for identifying them and uses

A - Human Necessities

61

K

A61K 38/55 (2006.01) A01H 5/00 (2006.01) C12Q 1/00 (2006.01)

Patent

CA 2362794

Method for identifying compounds that interfere with or modulate sister chromatid separation in animal or plant cells by modulating a protease with separin-like cysteine endopeptidase activity. Inhibitors of separin activity are useful in cancer therapy, to prevent birth defects and to increase ploidy in plants.

Cette invention a trait à une technique d'identification de composés interférant avec une séparation de chromatides soeurs ou modulant celle-ci dans des cellules animales ou végétales, par modulation d'une protéase avec une activité cystéine endopeptidase de type séparine. Ces inhibiteurs de l'activité séparine se révèlent des plus utiles en thérapie anticancéreuse, aux fins de la prévention d'anomalies congénitales et aux fins de l'accroissement de la ploïdie chez les végétaux.

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