Inhibitors of serine protease activity of matriptase or mtsp1

Details Inhibitors of serine protease activity of matriptase or mtsp1 Inhibitors of serine protease activity of matriptase or mtsp1

C - Chemistry, Metallurgy

07

C

C07C 311/00 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2422157

The present invention provides compounds which inhibit serine protease activity of matriptase or MTSP1. Also provided are pharmaceutical compositions comprising those compounds and methods of using the compounds and pharmceutical compositions to treat conditions ameliorated by inhibition of matriptase or MTSP1.

L'invention concerne des composés qui inhibent l'activité de la sérine protéase de matriptase, ou MTSP1. Par ailleurs, l'invention concerne des compositions pharmaceutiques renfermant ces composés ainsi que des méthodes d'utilisation de ces composés et de ces compositions pharmaceutiques pour traiter des états pathologiques qui s'améliorent avec l'inhibition de matriptase, ou MTSP1.

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