Inhibitors of serine proteases

Details Inhibitors of serine proteases Inhibitors of serine proteases

C - Chemistry, Metallurgy

07

D

C07D 487/10 (2006.01) A61K 31/407 (2006.01) A61P 31/12 (2006.01) C07D 498/10 (2006.01)

Patent

CA 2679426

The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention.

L'invention concerne des composés qui inhibent une activité de sérine protéase, en particulier l'activité de la NS3-NS4A protéase du virus de l'hépatite C. En tant que tels, ils agissent en interférant avec le cycle de vie du virus de l'hépatite C et sont également utiles en tant qu'agents antiviraux. L'invention concerne en outre des compositions comprenant ces composés pour une utilisation ex vivo ou pour une administration à un patient souffrant d'une infection VHC. L'invention concerne également des procédés de traitement d'une infection VHC chez un patient par administration d'une composition comprenant un composé de cette invention.

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