C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/10 (2006.01) A61K 38/07 (2006.01) C07K 5/08 (2006.01)
Patent
CA 2541634
The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection and to processes for preparing the compounds. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. The invention further relates to processes for preparing these compounds.
L'invention concerne des composés de formule (I) ou un de ses sels ou de ses mélanges pharmaceutiquement acceptables inhibant l'activité de la sérine protéase, en particulier l'activité de la NS3-NS4A protéase du virus de l'hépatite C. Les composés agissent par interférence avec le cycle de vie du virus de l'hépatite C et sont également utilisés en tant qu'agents antiviraux. L'invention concerne, de plus, des compositions comprenant lesdits composés utilisées ex vivo ou administrées à un patient souffrant d'une infection au HCV, ainsi que des procédés pour préparer lesdits composés. L'invention se rapporte également à des méthodes de traitement d'une infection au HCV chez un patient comprenant l'administration d'une composition comprenant un composé de l'invention. L'invention concerne, en outre, des procédés pour préparer lesdits composés.
Cottrell Kevin M.
Perni Robert B.
Pitlik Janos
Smart & Biggar
Vertex Pharmaceuticals Incorporated
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