Inhibitors of serine proteases, particularly hcv ns3-ns4a...

Details Inhibitors of serine proteases, particularly hcv ns3-ns4a... Inhibitors of serine proteases, particularly hcv ns3-ns4a...

C - Chemistry, Metallurgy

07

K

C07K 5/10 (2006.01) A61K 38/04 (2006.01) A61P 31/12 (2006.01)

Patent

CA 2532664

The present invention relates to compounds of formula I or formula Ia or pharmaceutically acceptable salts thereof, that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are useful as antiviral agents. The invention further relates to pharmaceutically acceptable compositions comprising said compounds either for ex vivo use or for administration to a patient suffering from HCV infection and processes for preparing the compounds. The invention also relates to methods of treating an HCV infection in a patient by15 administering a pharmaceutical composition comprising a compound of this invention.

La présente invention concerne des composés de formule I ou de formule Ia ou leurs sels pharmaceutiquement acceptables, qui inhibent l'activité des sérines protéases, en particulier l'activité de la protéase NS3-NS4A du virus de l'hépatite C. Lesdits composés agissent en interférant avec le cycle de vie du virus de l'hépatite C et sont utiles en tant qu'agents antiviraux. L'invention concerne également des compositions pharmaceutiquement acceptables comprenant lesdits composés, destinées à être utilisées ex vivo ou à être administrées à un patient atteint d'une infection par le VHC ainsi que des procédés de préparation desdits composés. L'invention concerne également des méthodes de traitement d'une infection par le VHC chez un patient par administration d'une composition pharmaceutique comprenant un composé selon l'invention.

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