C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/02 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) C07K 5/02 (2006.01) C07K 14/18 (2006.01)
Patent
CA 2554999
The present invention relates to compounds of formula (I), or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection and to processes for preparing the compounds. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. The invention further relates to processes for preparing these compounds.
L'invention porte sur des composés de formule (I) ou leurs sels pharmacocompatibles ou leurs mélanges, qui inhibent l'activité de la protéase sérine, et en particulier celle de la protéase NS3-NS4A du virus de l'hépatite C, en interférant avec son cycle de vie, tout en agissant en tant qu'agents antiviraux. L'invention porte également: sur des compositions comprenant lesdits composés soit pour des utilisations ex vivo, soit pour être administrées à des patients souffrant d'une infection par le VHC; sur des méthodes de traitement des infections par le VHC par administration à un patient d'une composition comprenant lesdits composés; et sur le procédé de préparation de ces composés.
Cottrell Kevin M.
Court John J.
Deininger David D.
Farmer Luc J.
Perni Robert B.
Smart & Biggar
Vertex Pharmaceuticals Incorporated
LandOfFree
Inhibitors of serine proteases, particularly hcv ns3-ns4a... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Inhibitors of serine proteases, particularly hcv ns3-ns4a..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of serine proteases, particularly hcv ns3-ns4a... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1863271