C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/117 (2006.01) A61K 38/07 (2006.01) A61L 2/16 (2006.01) A61P 31/14 (2006.01) C07K 5/103 (2006.01) C07K 7/06 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2405043
The present invention relates to compounds that are useful as protease inhibitors, particularly as serine protease inhibitors, and more particularly as hepatitis C NS3 protease inhibitors. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HCV NS3 protease activity and consequently, may be advantageously used as therapeutic agents against the hepatitis C virus and other viruses that are dependent upon a serine protease for proliferation. This invention also relates to methods for inhibiting the activity of proteases, including hepatitis C virus NS3 protease and other serine proteases, using the compounds of this invention and related compounds.
L'invention concerne des composés utiles comme inhibiteurs de protéases, notamment comme inhibiteurs de sérine protéases, et plus particulièrement comme inhibiteurs de la protéase NS3 de l'hépatite C. Ces composés agissent en interférant dans le cycle de vie du virus de l'hépatite C et sont également utiles comme agents antiviraux. L'invention concerne aussi des compositions pharmaceutiques contenant ces composés. Les composés et les compositions pharmaceutiques de l'invention conviennent particulièrement bien pour inhiber l'activité de la protéase NS3 du VHC, et peuvent par conséquent servir avantageusement d'agents thérapeutiques contre le virus de l'hépatite C et d'autres virus dont la prolifération dépend d'une sérine protéase. L'invention concerne aussi des procédés visant à inhiber l'activité de protéases, y compris de la protéase NS3 du virus de l'hépatite C et d'autres sérine protéases, au moyen des composés de l'invention et de composés associés.
Bhisetti Govinda Rao
Court John
O'malley Ethan
Perni Robert
Smart & Biggar
Vertex Pharmaceuticals Incorporated
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