Inhibitors of siderophore biosynthesis in fungi

A - Human Necessities – 61 – K

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61K 45/00 (2006.01) A61P 31/10 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2460873

The present invention relates to methods for screening inhibitors of siderophore biosynthesis in fungi, preferably in Aspergillus species, particularly preferred in Aspergillus fumigates comprising (a) contacting a cell expressing a fungal siderophore with a compound to be tested; (b) determining whether said cell is capable of siderophore biosynthesis in the presence of said compound to be tested when compared to a cell not contacted with said compound; and (c) identifying the compound which inhibits fungal siderophore biosynthesis. In another aspect the present invention relates to a method of preparing a pharmaceutical composition for treating diseases associated with fungal infections, particularly, aspergillosis or coccidiosis comprising (a) identifying a compound which inhibits fungal sideropore biosynthesis; and (b) formulating said compound with a pharmaceutically acceptable carrier. In a further aspect, the present invention relates to a method for the production of a pharmaceutical composition comprising the steps of the aforementioned screening method and the subsequent step of mixing the compound identified to be an inhibitor of fungal siderophore biosynthesis with a pharmaceutically acceptable carrier. Moreover, the present invention envisages a pharmaceutical composition comprising an inhibitor of fungal siderophore biosynthesis as well as the use of such an inhibitor for the preparation of a pharmaceutical composition for the prevention and/or treatment of diseases associated with fungal infections, particularly, aspergillosis or coccidiosis.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Inhibitors of siderophore biosynthesis in fungi does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibitors of siderophore biosynthesis in fungi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibitors of siderophore biosynthesis in fungi will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1935330

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.