Inhibitors of siderophore biosynthesis in fungi

Details Inhibitors of siderophore biosynthesis in fungi Inhibitors of siderophore biosynthesis in fungi

A - Human Necessities

61

K

A61K 45/00 (2006.01) A61P 31/10 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2460873

The present invention relates to methods for screening inhibitors of siderophore biosynthesis in fungi, preferably in Aspergillus species, particularly preferred in Aspergillus fumigates comprising (a) contacting a cell expressing a fungal siderophore with a compound to be tested; (b) determining whether said cell is capable of siderophore biosynthesis in the presence of said compound to be tested when compared to a cell not contacted with said compound; and (c) identifying the compound which inhibits fungal siderophore biosynthesis. In another aspect the present invention relates to a method of preparing a pharmaceutical composition for treating diseases associated with fungal infections, particularly, aspergillosis or coccidiosis comprising (a) identifying a compound which inhibits fungal sideropore biosynthesis; and (b) formulating said compound with a pharmaceutically acceptable carrier. In a further aspect, the present invention relates to a method for the production of a pharmaceutical composition comprising the steps of the aforementioned screening method and the subsequent step of mixing the compound identified to be an inhibitor of fungal siderophore biosynthesis with a pharmaceutically acceptable carrier. Moreover, the present invention envisages a pharmaceutical composition comprising an inhibitor of fungal siderophore biosynthesis as well as the use of such an inhibitor for the preparation of a pharmaceutical composition for the prevention and/or treatment of diseases associated with fungal infections, particularly, aspergillosis or coccidiosis.

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