C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/33 (2006.01) A61K 35/76 (2006.01) A61K 38/16 (2006.01) A61K 39/12 (2006.01) A61P 31/04 (2006.01) C07K 14/005 (2006.01) C07K 14/01 (2006.01) C07K 14/31 (2006.01) C12N 15/34 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2457220
The present invention discloses inhibitors of the primary sigma factor in Staphylococcus aureus (.sigma.SA), an essential protein implicated in RNA synthesis. The invention also discloses methods for inhibiting bacterial growth by contacting a bacterium with an antibacterial compound that specifically binds to a bacteriophage polypeptide binding domain of the Staphylococcus aureus primary sigma factor. Examples of inhibitors include bacteriophage polypeptides inhibiting growth of S. aureus and bacteriophage polypeptides binding specifically to S. aureus primary sigma factor. In addition, the invention discloses screening methods for identifying compounds which inhibit biochemical and/or cellular activity of S. aureus primary sigma factor.
Bergeron Dominique
Dehbi Mohammed
Dubow Michael
Gros Philippe
Mccarty John
Fasken Martineau Dumoulin Llp
Phagetech Inc.
Targanta Therapeutics Inc.
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