Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type...

Details Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type... Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type...

C - Chemistry, Metallurgy

07

D

C07D 207/26 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2646069

A compound of formula (I) or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof. Methods of inhibiting 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. Methods of treating non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.

La présente invention concerne un composé de formule (I) ou un sel, un promédicament, un sel de promédicament ou une combinaison de l'ensemble pharmaceutiquement acceptables. L'invention porte aussi sur des procédés permettant d'inhiber l'enzyme 11-bêta-hydroxystéroïde déshydrogénase de type 1. L'invention a trait à des procédés permettant de traiter des diabètes 2 non insulinodépendants, la résistance à l'insuline, l'obésité, les troubles lipidiques, un syndrome métabolique et d'autres maladies et états qui sont occasionnés par une action glucocorticoïde excessive.

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