Inhibitors of the advanced glycosylation of proteins and...

Details Inhibitors of the advanced glycosylation of proteins and... Inhibitors of the advanced glycosylation of proteins and...

A - Human Necessities

61

K

167/100, 99/18,

A61K 31/00 (2006.01) A23L 3/34 (2006.01) A61K 31/12 (2006.01) A61K 31/16 (2006.01) A61K 31/19 (2006.01) A61K 31/22 (2006.01) A61K 31/275 (2006.01) A61K 31/365 (2006.01)

Patent

CA 2039542

ABSTRACT OF THE DISCLOSURE The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with a carbonyl moiety of an early glycosylation product of such target proteins resulting from their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.

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