C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/04 (2006.01) C07D 403/02 (2006.01) C07D 487/02 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2718403
The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions asso-ciated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation.
La présente invention concerne des inhibiteurs à petite molécule de signalisation BMP. Ces composés peuvent être utilisés pour moduler les croissance, différenciation, prolifération et apoptose cellulaires, et peuvent donc être utiles pour traiter des maladies ou pathologies associées à la signalisation BMP, y compris linflammation, les maladies cardiovasculaires, les maladies hématologiques, le cancer, et les troubles osseux, ainsi que pour moduler la différenciation et/ou la prolifération cellulaires.
Bloch Kenneth D.
Cuny Gregory D.
Hong Charles C.
Peterson Randall T.
Yu Paul B.
Borden Ladner Gervais Llp
The Brigham And Women's Hospital Inc.
The General Hospital Corporation
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