C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61P 9/00 (2006.01) C07D 215/48 (2006.01) C07D 401/14 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2488193
The present invention relates to compounds of the formula (I); in which R1, R2, A, B, D, E, n, m or o have the meanings indicated below. The compounds of the formula (I) are valuable pharmacologically active compounds. They are reversible inhibitors of the interaction between the plasma protein von Willebrand factor (vWF) and the blood platelet receptor glycoprotein Ib-IX-V complex (GPIb). They exhibit an antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of atherothrombotic diseases.
la présente invention concerne des composés représentés par la formule (I) dans laquelle R1, R2, A, B, D, E, n, m ou o ont la signification qui leur est données dans le descriptif. Les composés représentés par la formule (I) sont de précieux composés actifs au plan pharmacologique. Ce sont des inhibiteurs réversibles de l'interaction entre le facteur von Willebrand (vWF) de la protéine plasmatique et le complexe glycoprotéique lf-IX-V (GPIb) de récepteur des plaquettes. Ces composés ont une action antithrombotique et conviennent notamment pour le traitement et la prévention des maladies athérothrombotiques.
Fukuchi Naoyuki
Just Melitta
Klingler Otmar
Sakurai Kuniya
Ajinomoto Co. Inc. Pharmaceutical Company
Aventis Pharma Deutschland Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis Deutschland Gmbh
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