C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/51 (2006.01) A61K 31/18 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) A61P 41/00 (2006.01) C07K 5/06 (2006.01) C07K 5/065 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2452322
This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds having the following structure (I), wherein A, B, R, R1, R1 p and q are as defined herein. The invention is also directed to pharmaceutical compositions containing one or more of these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
L'invention concerne de nouveaux composés inhibiteurs de la famille des oxamyl dipeptide ICE/ced-3, qui possèdent la structure (I), A, B, R, R¿1?, R¿1'? <i>p</i> et <i>q</i> étant tels que définis dans la demande. L'invention concerne aussi des compositions pharmaceutiques contenant un ou plusieurs de ces composés, ainsi que l'utilisation de ces compositions pour traiter des patients atteints de maladies inflammatoires, auto-immunes et neurodégénératives, prévenir des lésions ischémiques et conserver des organes destinés à une greffe.
Chao Bin
Gladstone Patricia L.
Linton Steven D.
Ternansky Robert J.
Tomaselli Kevin J.
Borden Ladner Gervais Llp
Idun Pharmaceuticals Inc.
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