Inhibitors of the ice/ced-3 family of cysteine proteases

Details Inhibitors of the ice/ced-3 family of cysteine proteases Inhibitors of the ice/ced-3 family of cysteine proteases

C - Chemistry, Metallurgy

07

C

C07C 311/51 (2006.01) A61K 31/18 (2006.01) A61P 7/00 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) A61P 41/00 (2006.01) C07K 5/06 (2006.01) C07K 5/065 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2395975

This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds having the structure (I) wherein A, B, R, R1, p and q are as defined herein. The invention is also directed to pharmaceutical compositions containing one or more of these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.

L'invention concerne de nouveaux composés inhibiteurs de la famille ICE/ced-3 oxamyldipeptidiques correspondant à la formule développée (I), dans laquelle A, B, R, R¿1?, p et q correspondent à la définition donnée dans la description. L'invention concerne également des compositions pharmaceutiques contenant au moins un de ces composés, ainsi que l'utilisation de telles compositions dans le traitement de patients souffrant de maladies inflammatoires, auto-immunes et neurodégénératives, pour la prévention de lésions ischémiques, et pour la conservation d'organes destinés à une transplantation.

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