A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/46 (2006.01) A61K 31/35 (2006.01) A61K 31/683 (2006.01) A61K 31/7088 (2006.01) A61K 31/7105 (2006.01) A61K 33/24 (2006.01) A61K 45/00 (2006.01) A61P 3/10 (2006.01) C12Q 1/00 (2006.01) C12Q 1/42 (2006.01)
Patent
CA 2388180
The present invention is related to an inhibitor of the inositol polyphosphate 5-phosphatase SHIP2 protein or its encoding nucleotide sequence identified by SEQ ID NO. 1 or of SHIP2 mRNA expression. The present invention is also related to a pharmaceutical composition comprising said inhibitor and an adequate pharmaceutically acceptable carrier or diluent and to a non-human knock-out mammal comprising homozygously or heterozygously a partial or total deletion in its genome of the inositol polyphoshate 5-phosphatase SHIP2 nucleotide sequence.
La présente invention concerne un inhibiteur de la protéine d'inositol polyphosphate 5-phosphatase SHIP2 ou de sa séquence nucléotide codante identifiée par SEQ ID NO. 1 ou de l'expression de l'ARN messager du SHIP2. L'invention concerne également, d'une part une composition pharmaceutique comprenant cet inhibiteur et un vecteur ou diluant approprié pharmaceutiquement admis, et d'autre part un mammifère non-humain anéanti dont le génome présente, de façon homozygote ou hétérzygote, une destruction totale ou partielle de la séquence de nucléotides de l'inositol polyphoshate 5-phosphatase SHIP2.
Erneux Christophe
Schurmans Stephane
Euroscreen Societe Anonyme
Smart & Biggar
LandOfFree
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