Inhibitors of the interaction between mdm2 and p53

Details Inhibitors of the interaction between mdm2 and p53 Inhibitors of the interaction between mdm2 and p53

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/538 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2699707

The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds: wherein n, s, t, R1, R2, R3, R4, R5, X, Y, Q, Z, G, E and D have defined meanings.

La présente invention concerne des composés de formule (I), leur utilisation en tant qu'inhibiteurs d'une interaction p53-MDM2 et des compositions pharmaceutiques qui comprennent lesdits composés : dans laquelle n, s, t, R1, R2, R3, R4, R5, X, Y, Q, Z, G, E et D ont des significations définies.

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