Inhibitors of the production of s-cd23 and the secretion of tnf

Details Inhibitors of the production of s-cd23 and the secretion of tnf Inhibitors of the production of s-cd23 and the secretion of tnf

C - Chemistry, Metallurgy

07

C

C07C 259/06 (2006.01) A61K 31/195 (2006.01) C07C 279/14 (2006.01) C07D 277/64 (2006.01) C07D 307/80 (2006.01) C07D 307/81 (2006.01) C07D 333/54 (2006.01) C07D 333/60 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2253590

Compounds of formula (I) wherein: R is hydroxy, hydrogen, alkyl, alkenyl, alkynyl or aryl; R1 is arylmethyl or heterocyclylmethyl; R2 is alkyl, alkenyl, aryl, cycloalkyl or cycloalkenyl; and R3 is hydrogen, alkyl, alkenyl, alkynyl or aryl; with the provisio that: if R1 is phenylmethyl or naphtylmethyl, wherein the phenyl or naphthyl group is unsubstituted or substituted by up to five substituents selected from the group consisting of halogen, (C1-6)alkyl, aryl(C1-6)alkyl, (C1-6)alkoxy, (C1-6)alkoxy(C1-6)alkyl, halo(C1-6)alkyl, hydroxy, nitro, amino, mono- and di-N-(C1-6)alkylamino, acylamino, acyloxy, carboxy, carboxy salts, carboxy esters, carbamoyl, mono- and di-N-(C1- 6)alkylcarbamoyl, (C1-6)alkoxycarbonyl, aryloxycarbonyl, ureido, guanidino, sulphonylamino, aminosulphonyl, (C1-6)alkylthio, (C1-6)alkyl sulphinyl (C1- 6)alkylsulphonyl, heterocyclyl, heterocyclyl (C1-6)alkyl, and a (C3-5)alkylene chain linking two adjacent ring carbon atoms to form a carbocyclic ring; then R is hydroxy; are useful in the treatment of disorders mediated by s-CD23.

Compositions de formule (I) utiles dans le traitement de troubles induits par s-CD23. Dans la formule (I), R représente hydroxy, alkyle, alcényle, alcynyle ou aryle; R?1¿ représente arylméthyle ou hétérocyclylméthyle; R?2¿ représente alkyle, alcényle, aryle, cycloalkyle ou cycloalcényle; et R?3¿ représente hydrogène, alkyle, alcényle, alcynyle ou aryle; à condition que: si R?1¿ représente phénylméthyle ou naphtylméthyle, le groupe phényle ou naphtyle étant substitué ou non par jusqu'à 5 substituants choisis dans le groupe comprenant halogène, (C¿1-6?)alkyle, aryl(C¿1-6?)alkyle, (C¿1-6?)alcoxy, (C¿1-6?)alcoxy(C¿1-6?)alkyle, halo(C¿1-6?)alkyle, hydroxy, nitro, amino, mono et di-N-(C¿1-6?)alkylamino, acylamino, acyloxy, carboxy, des sels carboxy, des esters carboxy, carbamoyle, mono et di-N-(C¿1-6?)alkylcarbamoyle, (C¿1-6?)alcoxycarbonyle, aryloxycarbonyle, uréido, guanidino, sulfonylamino, aminosulfonyle, (C¿1-6?)alkylthio, (C¿1-6?)alkylsulfynyle(C¿1-6?)alkylsulfonyle, hétérocyclyle, hétérocyclyl (C¿1-6?)alkyle, et une chaîne (C¿3-5?)alkylène liant deux atomes de carbones de noyaux adjacents pour former un noyau carbocyclique; R représente hydroxy.

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