C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/88 (2006.01) A61K 31/495 (2006.01) A61K 31/529 (2006.01) A61P 7/10 (2006.01) C07D 295/135 (2006.01) C07D 295/155 (2006.01) C07D 405/08 (2006.01) C07D 407/08 (2006.01) C07D 413/08 (2006.01) C07D 487/08 (2006.01) C07D 493/04 (2006.01)
Patent
CA 2759399
This invention relates to compounds having structural Formula I: and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir1.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.
La présente invention a pour objet des composés ayant la formule structurelle I : et leurs sels pharmaceutiquement acceptables qui sont des inhibiteurs du canal potassique médullaire externe rénal (ROMK) (Kir1.1). Les composés de Formule I sont utiles en tant que diurétiques et natriurétiques et sont par conséquent utiles pour la thérapie et la prophylaxie des troubles résultant d'une rétention excessive de sel et d'eau, comprenant les maladies cardiovasculaires telles que l'hypertension et l'insuffisance cardiaque chronique et aiguë.
Pasternak Alexander
Shahripour Aurash
Tang Haifeng
Teumelsan Nardos H.
Walsh Shawn P.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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