Inhibitors of the s100-p53 protein-protein interaction and...

Details Inhibitors of the s100-p53 protein-protein interaction and... Inhibitors of the s100-p53 protein-protein interaction and...

A - Human Necessities

61

K

A61K 31/553 (2006.01) A61K 31/00 (2006.01) A61K 31/09 (2006.01) A61K 31/12 (2006.01) A61K 31/13 (2006.01) A61K 31/15 (2006.01) A61K 31/155 (2006.01) A61K 31/17 (2006.01) A61K 31/185 (2006.01) A61K 31/27 (2006.01) A61K 31/341 (2006.01) A61K 31/4035 (2006.01) A61K 31/4152 (2006.01) A61K 31/435 (2006.01) A61K 31/44 (2006.01) A61K 31/4425 (2006.01) A61K 31/47 (2006.01) A61K 31/53 (2006.01) A61K 31/635 (2006.01) A61P 35/00 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2480194

Compounds that bind S100 and inhibit the S100-p53 protein-protein interaction and activate the tumor supressor activity of p53, and thus which have an antineoplastic effect are disclosed, as well as methods for identifying these compounds, compositions comprising the same, and methods of using the same to treat cancer.

L'invention concerne des composés qui se lient à S100, inhibent l'interaction protéine-protéine S100-p53 et amorcent l'activité de suppression des tumeurs de p53, ces composés présentant un effet antinéoplasique. L'invention concerne également des méthodes d'identification desdits composés, des compositions les contenant, ainsi que des méthodes d'utilisation de ces composés dans le traitement du cancer.

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