C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/435 (2006.01) A61K 31/4365 (2006.01) A61K 31/4375 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01) C07D 221/04 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 495/14 (2006.01) C12N 9/99 (2006.01) C07K 14/705 (2006.01) C12N 9/12 (2006.01) C12N 9/22 (2006.01)
Patent
CA 2638734
Compounds that are inhibitors of the unfolded protein response and endonuclease IRE1 are provided, together with compositions comprising such compounds, and methods for their use in the treatment of various disorders, such as cancer, autoimmune disorders, and diabetes. Also provided are packaged pharmaceuticals comprising these compositions. The compositions may be administered in combination with another therapeutic agent.
L'invention porte sur des inhibiteurs de la réponse aux protéines dépliées et sur l'endonucléase IRE1, ainsi que sur des compositions renfermant lesdits composés, et sur des procédés associés utilisés pour traiter diverses pathologies, telles que le cancer, les maladies autoimmunes et le diabète. L'invention porte également sur des produits pharmaceutiques conditionnés renfermant lesdites compositions. Ces compositions peuvent être administrées en combinaison avec un autre agent thérapeutique.
Feldman Douglas E.
Koong Albert C.
Smart & Biggar
The Board Of Trustees Of The Leland Stanford Junior University
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