Inhibitors of thrombin

Details Inhibitors of thrombin Inhibitors of thrombin

C - Chemistry, Metallurgy

07

K

C07K 14/81 (2006.01) A61K 38/10 (2006.01) A61K 38/49 (2006.01) A61K 38/55 (2006.01) A61K 51/08 (2006.01) A61L 33/00 (2006.01) C07K 7/02 (2006.01) C07K 7/08 (2006.01) C07K 14/815 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2065150

This invention relates to novel biologically active molecules which bind to and inhibit thrombin. Specifically, these molecules are characterized by a thrombin anion-binding exosite association moiety (ABEAM); a linker portion of at least 18.ANG. in length; and a thrombin catalytic site-directed moiety (CSDM). This invention also relates to compositions, combinations and methods which employ these molecules for therapeutic, prophylactic and diagnostic purposes.

Cette invention concerne de nouvelles molécules biologiquement actives qui se lient à la thrombine et l'inhibent. Plus particulièrement, ces molécules se caractérisent par une fraction d'associations anion de thrombine-exosite de liaison (ABEAM); une portion de liaison d'au moins 18Å de longueur; et une fraction orientée sur le site catalytique de la thrombine (CSDM). Cette invention concerne également des compositions, des combinaisons et des procédés qui utilisent ces molécules à des fins thérapeutiques, prophylactiques et diagnostiques.

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