Inhibitors of transcription factor nf-.kappa.b

A - Human Necessities – 01 – N

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A01N 37/18 (2006.01) C07C 235/64 (2006.01)

Patent

CA 2335294

The present invention provides pharmaceutical compositions of salicylanilide inhibitors of transcription factor NF-.kappa.B, and methods for treating diseases in which activation of NF-.kappa.B is implicated. More specifically, the present invention provides methods of treatment of a variety of diseases associated with NF-.kappa.B activation including inflammatory disorders; particularly rheumatoid arthritis, inflammatory bowel disease, and asthma; dermatosis, including psoriasis and atopic dermatitis; autoimmune diseases; tissue and organ rejection; Alzheimer's disease; stroke; atherosclerosis; restenosis; cancer, including Hodgkin's disease; certain viral infections, including AIDS; osteoarthritis; osteoporosis; and Ataxia Telangiestasia by administering to a patient in need thereof a compound of the present invention.

La présente invention concerne des compositions pharmaceutiques d'inhibiteurs salicylanilides du facteur de transcription NF-.kappa.B, ainsi que des méthodes de traitement des maladies dans lesquelles l'activation de ce NF-.kappa.B est impliquée. Plus spécifiquement, la présente invention concerne des méthodes permettant de traiter différentes maladies associées à l'activation dudit NF-.kappa.B, notamment les troubles inflammatoires, et en particulier la polyarthrite rhumatoïde, l'affection intestinale inflammatoire, et l'asthme; la dermatose, notamment le psoriasis et l'eczéma constitutionnel; les maladies auto-immunes; le rejet de tissus ou d'organes; la maladie d'Alzheimer; les accidents cérébrovasculaires; l'athérosclérose; la resténose; le cancer, notamment la maladie de Hodgkin; certaines infections virales, y compris le SIDA; l'arthrose; l'ostéoporose; et l'ataxie télangiectasie. Les méthodes de cette invention consistent à administrer à un patient nécessitant un tel traitement un des composés susmentionnés.

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