Inhibitors of tumor necrosis factor alpha

Details Inhibitors of tumor necrosis factor alpha Inhibitors of tumor necrosis factor alpha

C - Chemistry, Metallurgy

07

D

C07D 209/48 (2006.01) A61K 31/4035 (2006.01) C07D 209/46 (2006.01)

Patent

CA 2230487

Novel nitriles are inhibitors of tumor necrosis factor .alpha. and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions. A typical embodiment is 3-Phthalimido-3-(3,4-dimethoxyphenyl)propionitrile.

Il est possible d'utiliser de nouveaux nitriles, inhibiteurs du facteur de nécrose des tumeurs .alpha. et de la photodiestérase, pour lutter contre la cachexie, le choc endotoxinique, la réplication rétrovirale, l'asthme et les états inflammatoires. Une réalisation typique en est 3-Phtalimido-3-(3,4-diméthoxyphényl)proprionitrile.

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