Inhibitors of tyrosine kinases and uses thereof

Details Inhibitors of tyrosine kinases and uses thereof Inhibitors of tyrosine kinases and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 471/06 (2006.01) A61K 31/416 (2006.01) A61K 31/4375 (2006.01) A61K 31/675 (2006.01)

Patent

CA 2636696

Disclosed herein are compounds that inhibit the activity of particular tyrosine kinases. Methods for the preparation of such compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the compounds disclosed, alone or in combination with other therapeutic agents, for the treatment of tyrosine kinase-rnediated diseases or conditions or tyrosine, kinase-dependent diseases or conditions are provided.

La présente invention concerne des composés qui inhibent l~activité d~une tyrosine kinase spécifique. Les procédés de préparation de tels composés sont présentés. Sont également indiquées des compositions pharmaceutiques qui les comprennent. Sont aussi proposés des procédés d~utilisation des composés présentés, seuls ou en combinaison avec d~autres agents thérapeutiques, pour le traitement de maladies produites par la tyrosine kinase ou de conditions ou de maladies dépendant de la tyrosine kinase.

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